Correlation between D-lactate and disease severity in patients with NAFLD
Next, we assessed the correlations between D-lactate level and the clinical parameters identified as differing in NAFLD patients with and without elevated intestinal permeability. As shown in Table 3, D-lactate was positively correlated with ALT (r=0.312, P˂0.001); AST (r=0.303, P˂0.001); GGT (r=0.190, P=0.017); TBIL (r=0.214, P=0.004); IBIL (r=0.247, P=0.001); FAP (r=0.252, P=0.001); TG (r=0.173, P=0.021); and DAO (r=0.218, P=0.002). A positive correlation was also detected between D-lactate and LPS, although it was not statistically significant (r=0.132, P=0.069). However, D-lactate did not correlate with DBIL, LSM, TC, HDL, LDL, and HOMA-IR values (Table 3 ).