Acupuncture effects on IVF outcomes
As shown in Table 1 , pooled CPR and LBR data showed a significant difference between acupuncture and control groups (60 trials, OR=1.65, 95%CI: 1.45 to 1.88; 20 trials, OR=1.34, 95%CI: 1.08 to 1.66, respectively). However, acupuncture had no significant improvement for OPR (11 trials, OR=1.33, 95%CI=0.93 to 1.89) (Table S4 ). Table S5 showed the subgroup analysis for CPR of TA by control type.
As for the effects of different acupuncture methods and shown inTable 1 , only TEAS was found to be a positive effect for both CPR (10 trials, OR=1.37, 95%CI=1.21 to 1.56) and LBR (7 trials, OR=1.74, 95%CI=1.23 to 2.46). In addition, 28 studies used TA (OR=1.24, 95%CI=1.15 to 1.33), 6 studies used WA (OR=1.75, 95%CI=1.33 to 2.32), 7 studies used EA (OR=1.45, 95%CI=1.13 to 1.85) and 2 studies used LA (OR=1.22, 95% CI=1.06 to 1.41) showed a positive improvement for CPR results. 33 trials reported MR and statistically significant difference was found between TA and no treatment group (OR=1.44, 95% CI=1.00 to 2.07) (Figure S3 ). Table S6 showed the risk of adverse events were higher in acupuncture (6.59% vs 1.09%, p <0.001) than no treatment group, but no significant difference compared with sham or placebo acupuncture (47.61% vs 44.26%, p =0.241).