1Additionally adjusted for body mass index, estimated creatinine clearance and donors’ ABCC2 1249 G>Agenotype.
AUCt,ss – area under the concentration-time curve during dosing interval at steady-state; Cmax,ss – peak plasma concentration at steady-state; C0 – morning pre-dose trough; C12 – evening trough; CLT/Fss – apparent total body clearance at steady-state