Methods
In this retrospective study, the patients admitted to Ophthalmology
and Hematology Division were enrolled between February 1, 2018, and
November 30, 2019. The patients who admitted to the ophthalmology
outpatient clinic due to once or recurrent SCH, underwent a complete
ophthalmologic examination, including the best corrected visual acuity
level, slit-lamp biomicroscopy, intraocular pressure measurement with
Goldmann applanation tonometer and dilated fundoscopy. Patients who
didn’t have any etiological reasons for bleeding such as conjunctivitis, episcleritis, keratitis, corneal ulcer,
glaucoma, dry eye and blepharitis, were referred to the hematology
outpatient clinic for evaluation of bleeding disorders.
All patients were questioned for ocular trauma (including the usage of
lenses), systemic hypertension, diabetes, cardiovascular abnormalities,
fever and medications affecting platelet function or blood clotting,
such as nonsteroidal anti-inflammatory drugs, aspirin, antiplatelet
agents, heparin, oral anticoagulants, anti-vitamin K or non-vitamin K
oral anticoagulants (NOACs), steroids, antiepileptics or
antidepressants and if any, they were excluded from the study.
Patients’ bleeding histories were also evaluated using a standardized
bleeding assessment tool (BAT) created by International Society on
Thrombosis and Hemostasis (ISTH).
Complete blood count (CBC), prothrombin time (PT), activated partial
thromboplastin time (aPTT), fibrinogen, factor VIII, von Willebrand
factor antigen (vWF Ag), von Willebrand factor ristocetin cofactor (vWF
Rco) and factor XIII antigen levels were tested from all patients meeting inclusion criterias. PFA-100 (collagen / epinephrine (C / Epi),
collagen / ADP (C / ADP) and closure time (CT) were studied in available
patients. Thrombin time was studied in a small number of patients.
According to these laboratory results, the patients with the hemorrhagic
disorders were determined and SCH with once and those with 2 or more
were compared for the laboratory results.
Statistical Package for the Social Sciences (SPSS) version 15.0 was used
for the analysis. The distribution of the datas were assessed using a
one-sample Kolmogorov-Smirnov test. Normally distributed continuous
variables were expressed as the mean±SD, skew-distributed continuous
variables were expressed as the median (minimum-maximum), and
categorical variables were expressed as the number and percentage. For
comparison of categorical variables, Fisher’s exact test or a chi-square
test was used. Differences between
numeric variables were tested with Student’s t-test or a Mann-Whitney
U-test, where appropriate. A p-value of less than 0.05 was considered as
statistically significant.
All procedures performed in studies involving human participants were in
accordance with the ethical standards of the institutional and/or
national research committee and with the 1964 Helsinki declaration and
its later amendments or comparable ethical standards. (Kecioren
Educational and Research Hospital-08.01.2020/2027)