What’s already known about this topic?
Raynaud’s phenomenon (RP) is a reversible vasospastic disorder that may
be provoked by cold or emotional stress. This phenomenon can be occur
without underlying disease or unknown etiology which named as primary RP
(pRP). The essential finding of pRP is aggravation of symptoms by
exposure cold and the detection of color changes (turn white, blue, or
both). The diagnosis is clarified after exclusion of possible underlying
diseases with checking nail capillaroscopy and laboratory panel such as
complete blood counting, inflammatory parameters, metabolic panel,
antibodies, enzymes etc. However, any specific laboratory marker was not
determined for diagnosing pRP. Therefore, researchers tried to determine
an objective laboratory marker that is highly specific and scientific
for pRP.