Conclusions
Supportive care for children with cancer may be augmented by our findings, but further exploration of relationships between posture and QOL in a large RCT is warranted. Although many questions remain about posture as a potential physical sign of QOL in children, evidence supports the suggestion traced back to Darwin that this biobehavioral pathway may provide a novel method to measure QOL in pediatric oncology. An accurate objective measure of QOL could provide an efficient tool to augment the outcome measurements of interventions to reduce distress in children receiving treatment for cancer.