Structural alignment and visualization
In order to evaluate the degree of structural similarity between each human model and their corresponding orthologs, we carried out a structural alignment protocol using the Alignment/Superposition function of the Pymol molecular visualizer plugin [36]. PyMOL is a cross-platform tool for molecular graphics and it has been popularly used for the 3D visualization of trajectories, surfaces, electron densities, small molecules, nucleic acids and proteins. The tool is also used for movie making, molecule editing and ray tracing. PyMOL being a Python-based software has been designed along with many plugin tools to facilitate its usage for the 3D visualization of macromolecules as performed in this study [36].