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\begin{document}

\title{HDL SUBGROUPS AND THEIR PARAOXONASE-1 ACTIVITY IN THE OBESE, OVERWEIGHT
AND NORMAL WEIGHT SUBJECTS}



\author[1]{KÜBRA DOĞAN}%
\author[2]{mehmet senes}%
\author[2]{ANARA KARACA}%
\author[3]{DAMLA KAYALP}%
\author[4]{SEYFULLAH KAN}%
\author[5]{Nese Ersoz Gulcelik}%
\author[6]{YALÇIN ARAL}%
\author[7]{Dogan Yucel}%
\affil[1]{Sivas Numune State Hospital}%
\affil[2]{Ankara Training and Research Hospital}%
\affil[3]{Yozgat City Hospital, Ministry of Health}%
\affil[4]{Süleyman Demirel University Faculty of Medicine}%
\affil[5]{Gülhane Training and Research Hospital, Ministry of Health}%
\affil[6]{Yozgat Bozok University Faculty of Medicine}%
\affil[7]{Lokman Hekim Universitesi}%


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  \date{May 24, 2024}


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\begin{abstract}
ABSTRACT Background: Obesity and overweight are significant public
health problems due to higher risk for coronary artery disease (CAD). It
is very important to determine new predictive markers to identify the
CAD risk in obese and overweight. To this aim, we analyzed HDL-C
subclass and their paraoxonase-1 (PON-1) activity in obese, overweight
and normal weight subjects. Method: 71 newly diagnosed obese, 40
overweight and 30 healthy subjects as a control group were enrolled the
study. Serum lipids levels were determined with enzymatic colorimetric
method. PON-1 activities and HDL-3 levels were determined by
spectrophotometric methods. Non-HDL3-C concentrations were calculated
with the subtraction of HDL3-C from total HDL-C. Results: The mean serum
levels of total HDL-C, HDL3-C, Non-HDL3-C -C and ApoA1 were higher in
control group than obese and overweight groups. There were a
statistically significant difference between obese and control group in
terms of Lp(a), hsCRP and HOMA index. Higher total PON-1, non-HDL3 PON-1
and HDL3 PON-1 activities were found in the control group compared to
obese and overweight groups. Total HDL was weakly negative correlated
with the HOMA index, BMI and waist circumference. There was a weak
negative correlation between non-HDL3-C and waist circumstance.
Conclusion: Abnormal HDL-subgroups pattern and decreased PON-1
activities causes increased risk for CVD in obese and overweight
individuals. Therefore determination of HDL subgroups and their PON-1
activity improves risk prediction compared with measuring total HDL-C
levels and its PON-1 activity alone. Body weight and insulin resistance
appear to have a role in the decreased HDL-C levels and PON-1activity in
obese.%
\end{abstract}%



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