Secondary outcome data/other analyses:
We compared characteristics of children with a first negative test within 30 days of their initial SARS-CoV-2 diagnosis compared with children with a first negative test after 30 days (Table 2). Children who took >30 days for their SARS-CoV-2 tests to turn negative were more likely to be receiving chemotherapy and steroids, but these findings were not statistically significant. In our cohort, of the 30 children who were hospitalized, 23 (77%) hospitalizations were related to COVID-19 illness, with 3 children requiring ICU admission. One patient died from ARDS. This patient was a 20-year-old male day +127 post matched unrelated donor for treatment-induced leukemia. He presented to clinic with a known SARS-CoV-2 positive test, progressive shortness of breath, tachypnea, and baseline oxygen saturation in the 80-85% range. The patient had worsening respiratory and cardiac function and progressed to positive pressure ventilation with intubation on day 12 of admission and extracorporeal membrane oxygenation (ECMO) on day 25 of admission. SARS-CoV-2 directed therapy for this patient included remdesivir (10-day course), prednisone, and anakinra in consultation with infectious diseases and rheumatology. Following further worsening lung and right heart function, the family elected to withdraw life-sustaining treatment on day 37 of admission.