Secondary outcome data/other analyses:
We compared characteristics of children with a first negative test
within 30 days of their initial SARS-CoV-2 diagnosis compared with
children with a first negative test after 30 days (Table 2). Children
who took >30 days for their SARS-CoV-2 tests to turn
negative were more likely to be receiving chemotherapy and steroids, but
these findings were not statistically significant. In our cohort, of the
30 children who were hospitalized, 23 (77%) hospitalizations were
related to COVID-19 illness, with 3 children requiring ICU admission.
One patient died from ARDS. This patient was a 20-year-old male day +127
post matched unrelated donor for treatment-induced leukemia. He
presented to clinic with a known SARS-CoV-2 positive test, progressive
shortness of breath, tachypnea, and baseline oxygen saturation in the
80-85% range. The patient had worsening respiratory and cardiac
function and progressed to positive pressure ventilation with intubation
on day 12 of admission and extracorporeal membrane oxygenation (ECMO) on
day 25 of admission. SARS-CoV-2 directed therapy for this patient
included remdesivir (10-day course), prednisone, and anakinra in
consultation with infectious diseases and rheumatology. Following
further worsening lung and right heart function, the family elected to
withdraw life-sustaining treatment on day 37 of admission.