Study objectives
The primary objective of this study was to elucidate the incidence of
rhabdomyolysis following type A aortic dissection surgeries and to
correlate it’s the severity with the patient outcome –primarily in
terms of renal function. Other outcome measures included mechanical
ventilation duration, length of ICU stay, duration of hospital stay, and
mortality. We also proposed to formulate a risk scoring system based on
preoperative and intraoperative variables to predict the development of
RML after AAD surgery
Study definitions:
We followed the same definition for Rhabdomyolysis which we used in our
previous study.
In cardiac surgery, a higher cut off value (2500 U/L) to diagnose RML is
proposed to account for the release of CK from related myocardial injury1. Patients were divided into two groups based on this
diagnostic cutoff; Group A with RML (CK value above 2500 U/L) & Group B
without RML (CK below 2500 U/L). Acute kidney injury was defined using
the KDIGO criteria AKI – KDIGO criteria define AKI as a 0.3 mg/dl
(≥26.5 µmol/l) Serum Creatinine increase from baseline within 48 hours
of surgery, a 1.5 times Serum Creatinine increase from baseline within 7
days of surgery17. The original KDIGO criteria also
use urine output below 0.5 ml/kg/hour for 6 hours to define AKI. Urine
output criteria were not used to define AKI in our study due to data
collection difficulties, as adopted from a similar study on the
subject9.