Figure 8. Compound 270 affects various molecular mechanism involved in the pathogenesis of acute kidney and lung injury challenged with intraperitoneal injection of LPS
(A) The activity of MPO in kidney tissues, (n = 6). (B) The content of MDA in kidney tissues, (n = 6). (C) The ER stress relative proteins BiP and CHOP, as well as the autophagy associated proteins LC3A and p62 in kidney tissues were determined by western blotting, (n = 6). (D) The protein levels shown in (C) were quantified by densitometry analysis, (n = 6). (E) The activity of MPO in lung tissues, (n = 6). (F) The content of MDA in lung tissues, (n = 6). (G) The ER stress relative proteins BiP and CHOP, as well as the autophagy associated proteins LC3A and p62 in lung tissues were determined by western blotting, (n = 6). (H) The protein levels shown in (G) were quantified by densitometry analysis, (n = 6). The data are presented as the means ± SEM. One-tailed Student’s t-test. *P < 0.05, **P <0.01, ***P < 0.001 compared with the LPS group.
Figure 9