Figure 8. Compound 270 affects various molecular mechanism
involved in the pathogenesis of acute kidney and lung injury challenged
with intraperitoneal injection of LPS
(A) The activity of MPO in kidney tissues, (n = 6). (B) The content of
MDA in kidney tissues, (n = 6). (C) The ER stress relative proteins BiP
and CHOP, as well as the autophagy associated proteins LC3A and p62 in
kidney tissues were determined by western blotting, (n = 6). (D) The
protein levels shown in (C) were quantified by densitometry analysis, (n
= 6). (E) The activity of MPO in lung tissues, (n = 6). (F) The content
of MDA in lung tissues, (n = 6). (G) The ER stress relative proteins BiP
and CHOP, as well as the autophagy associated proteins LC3A and p62 in
lung tissues were determined by western blotting, (n = 6). (H) The
protein levels shown in (G) were quantified by densitometry analysis, (n
= 6). The data are presented as the means ± SEM. One-tailed Student’s
t-test. *P < 0.05, **P <0.01, ***P < 0.001
compared with the LPS group.
Figure 9