Advantages Disadvantages
Better predictor of vancomycin efficacy among other pharmacokinetic parameters [21]. Lower risk of vancomycin associated nephrotoxicity [21]. Less vancomycin exposure in AUC target range of 400-600 µg.h/ml in comparison to the target trough concentration of 15-20 µg/ml [21]. Shorter duration of antibiotic therapy [21]. Multiple samplings are required. Difficulty and complexity of AUC calculation. Controversies regarding the upper limit of AUC. Target AUC24h/MIC range of 400-600 µg.h/ml cannot be attributed to other Gram-positive microorganisms that are less virulent than MRSA [19]. AUC target concentration of >400 µg.h/ml was not correlated with reduced mortality in severe MRSA infections [19].