Comparison between CysC and Scr
The estimated PPK parameters between CysC-model and Scr-models were similar (Table 2). CysC significantly improved model fit (ΔOFV = -3.87,P < 0.05) compared with Scr and explained more inter-individual variability for CL (26.4% vs 23.3%), which suggested CysC had a better predictive performance for MPA CL. Furthermore, CKD staging graded by eGFR derived from CysC and Scr were divergent. The prevalence of eGFR of less than 60 mL/min/1.73 m2 was higher with the CysC-eGFR than with the Scr-eGFR (61.1% vs 72.2%). A total of 52 patients were with eGFR>30 mL/min/1.73 m2(CKD 1~3 stages) when using eGFRScr, however, 31 of them were reclassified into a lower stage when using eGFRCysC (Figure 5).