Patient characteristics
A total of 391 samples were performed in 25 patients ranging from 1 to
17 years of age (Figure 1). Sixteen children were MPO-ANCA and the rest
were
negative.
Patient characteristics were summarized in Table 1.
MPA-AUC0–12h showed a large inter-individual
variability, with a value of 45.11±30.26 mg/L·h. Trough level was
3.1±3.2 mg/L. There were significant correlations between MPA
AUC0–12h and concentration at each time with
C0h (r =0.73, P < 0.0001),
C0.33h (r =0.78, P < 0.0001),
C1h (r =0.84, P < 0.0001) and
C3h (r =0.85, P < 0.0001).