Evaluation and validation
Final model was evaluated by the
minimum OFV and goodness-of-fit plots. A bootstrap with 1,000 replicates
was performed to verify the accuracy and stability of the model, and the
parameters were summarized as the median and 95% confidence interval
(CI). Furthermore, visual predictive checks (VPC) with 1,000 simulations
were performed to assess the predictive performance of model. The
observed 5th, 50th, and 95th percentiles were plotted with their
respective simulated 95% CI.