Parameter Base model Cystatin C model Creatinine model Bootstrapb Bootstrapb
Estimate Estimate Estimate Median 95% CI
Structural parameters
Ka (h-1) 0.19 0.45 0.44 0.51 0.30-1.78
CL (L/h) 11.16 9.86 9.44 9.47 6.66-12.28
Q (L/h) 22.35 23.02 23.10 22.91 16.17-33.29
Vc (L) 19.42 19.69 19.38 21.49 10.91-81.52
Vp (L) 523.26 408.33 436.39 404.37 217.07-740.10
θDosage2 - -0.45 -0.44 -0.48 -0.82-(-0.03)
θDosage3 - -0.96 -0.96 -0.97 -0.99-(-0.86)
θCystatin C - -0.54 - -0.55 -0.81-(-0.29)
θSerum creatinine - - -0.36 - -
θmyeloperoxidase - 0.15 0.16 0.17 0.07-0.30
θAlbumin - 5.07 5.11 4.86 0.61-7.64
Interindividual variability
ω_Ka 1.64 1.07 1.08 1.07 -
ω_CL 1.02 0.74 0.78 0.74 -
ω_Vp 1.13 0.70 0.68 0.70 -
Residual variabilitya
Proportional 0.423 0.421 0.422 0.415 -
Additive 0.042 0.0010 0.0010 0.0010 -
OFV 1774.00 1673.89 1677.76 1673.89
Cystatin C model: Ka (h-1) = 0.45 · [1+(-0.449) · (if dosage=capsule preparations)] · [1+(-0.959) · (if dosage=enteric-coated tablets)]; CL (L/h) = 9.86 · (cystatin C/4.21) -0.543 · (myeloperoxidase/36.5) 0.154; Vp (L) = 408.33 · (albumin/39.3); Cystatin C model: Ka (h-1) = 0.45 · [1+(-0.449) · (if dosage=capsule preparations)] · [1+(-0.959) · (if dosage=enteric-coated tablets)]; CL (L/h) = 9.86 · (cystatin C/4.21) -0.543 · (myeloperoxidase/36.5) 0.154; Vp (L) = 408.33 · (albumin/39.3); Cystatin C model: Ka (h-1) = 0.45 · [1+(-0.449) · (if dosage=capsule preparations)] · [1+(-0.959) · (if dosage=enteric-coated tablets)]; CL (L/h) = 9.86 · (cystatin C/4.21) -0.543 · (myeloperoxidase/36.5) 0.154; Vp (L) = 408.33 · (albumin/39.3); Cystatin C model: Ka (h-1) = 0.45 · [1+(-0.449) · (if dosage=capsule preparations)] · [1+(-0.959) · (if dosage=enteric-coated tablets)]; CL (L/h) = 9.86 · (cystatin C/4.21) -0.543 · (myeloperoxidase/36.5) 0.154; Vp (L) = 408.33 · (albumin/39.3); Cystatin C model: Ka (h-1) = 0.45 · [1+(-0.449) · (if dosage=capsule preparations)] · [1+(-0.959) · (if dosage=enteric-coated tablets)]; CL (L/h) = 9.86 · (cystatin C/4.21) -0.543 · (myeloperoxidase/36.5) 0.154; Vp (L) = 408.33 · (albumin/39.3); Cystatin C model: Ka (h-1) = 0.45 · [1+(-0.449) · (if dosage=capsule preparations)] · [1+(-0.959) · (if dosage=enteric-coated tablets)]; CL (L/h) = 9.86 · (cystatin C/4.21) -0.543 · (myeloperoxidase/36.5) 0.154; Vp (L) = 408.33 · (albumin/39.3);