Figure 6. Schematic diagram of potential
Tr17 cells increased in LNs before induction of CIA and Tr17 cells increased during the clinical course of CIA and accumulated in inflamed joints. Tr17 cells highly expressed CD25, CTLA4, GITR, and ICOS molecules and over-produced IL-10. Tr17 cells suppressed proliferation of conventional T cells. Tr17 cells played a crucial role in the regulation of autoimmune arthritis trough infiltration into ankle joints.