Cor-Knot device is an automated suture fastening system which was introduced to minimize the operating time during cardiac surgery. It is currently being used for intracardiac suturing applications such as implanting valves or rings during aortic and mitral valve surgery primarily for shortening the procedure time. It also has higher holding pressures and more consistent holding pressures than manual knots. We describe here the use of Cor-Knot device in extracardiac suturing to secure aortic root vent as well as aortic cannulation during minimally invasive cardiac surgery. A 60-year-old male with mitral valve endocarditis underwent minimally invasive mitral valve replacement via right mini thoracotomy. Direct ascending aortic cannulation was performed through a separate port. Cor-Knots were successfully used to secure the purse-string sutures after decannulation at the end of the case.