Introduction
COVID-19 infection emerged in Wuhan, China in December 2019 (1) and
rapidly expanded worldwide as a cause of severe acute respiratory
syndrome (SARS-CoV-2), affecting more severely older adults with
comorbidities. In late April 2020 severe forms of SARS-CoV-2 infection
in children with shock and Kawasaki disease-like features (2, 3) were
reported in the UK and Italy. In the initial report, macrophage
activation syndrome (MAS) features were described in 5 of 10 patients
diagnosed with this complication (3). However, hemophagocitosis has not
been described in patients with MIS-C. We report two infants diagnosed
with MIS-C who presented MAS who responded to biological and
immunosuppressants therapies.