Introduction
COVID-19 infection emerged in Wuhan, China in December 2019 (1) and rapidly expanded worldwide as a cause of severe acute respiratory syndrome (SARS-CoV-2), affecting more severely older adults with comorbidities. In late April 2020 severe forms of SARS-CoV-2 infection in children with shock and Kawasaki disease-like features (2, 3) were reported in the UK and Italy. In the initial report, macrophage activation syndrome (MAS) features were described in 5 of 10 patients diagnosed with this complication (3). However, hemophagocitosis has not been described in patients with MIS-C. We report two infants diagnosed with MIS-C who presented MAS who responded to biological and immunosuppressants therapies.