BAY11-7082 treats EAN
BAY11-7082 (Beyotime, China) was dissolved in 1% dimethyl sulfoxide
(DMSO, USA) in PBS. EAN mice were divided into three groups. For
preventative treatment, BAY11-7082 solution was administered by
intraperitoneal injection (20 mg/kg) from day 1 to days 16
post-immunization (p.i.) by every two days. For therapeutic treatment,
BAY11-7082 solution was administered by the same way as the preventative
treatment at the same dose from the day on which the onset of symptoms
was observed to day 30 by every two days. Control animals with EAN
received the same volume of the vehicle solution (1% DMSO in PBS).
Using the same protocol descripted as the above assessed the clinical
signs of mice.