BAY11-7082 alters the expression of cytokines
The expression of inflammatory cytokines shapes the outcome of EAN
[15]. We used the CBA to confirm the
relevant changes in cytokines of EAN after treatments with
BAY11-7082.
That is, the expressions of TNF-α, IL-6 and IL-12 were greatly reduced
in BAY11-7082 preventative group compared to control and therapeutic
groups (p<0.01) (Fig. 3f). However, there were no marked
differences for the expression of IL-4, IL-10, IL-1β and IL-17A among
the three groups (Fig. 3f). Besides, the differences regarding the
expression of cytokines that were mentioned on above in the control and
therapeutic groups were meaningless.