Figure 1. The clinical scores of EAN after immunization. EAN was induced in C57BL/6 mice by immunization with P0 peptide 180-199 in combination with complete Freund’s adjuvant (FCA). The mice in the control group received FCA only. The statistically significant differences occurred from days 10 to day 15 post immunization (p.i.) (p﹤0.05 on each time point). The mean peak clinical scores were 2.6± 0.47 in the EAN group.