OFC
Two hundred and twelve (n=212) OFCs were performed to assess tolerance. A first OFC was performed in 173 children at 2.0 years of age (1.5-2.9), with a success rate of 74.0%. A second OFC was performed in 33 children at 2.3 years of age (2.0-3.5), with a success rate of 57.6%. A third OFC was performed in 6 children at 3.1 years of age (2.6-3.8), with a success rate of 100%. The interval between two OFCs was 11.7 months (7.0-15.8). In 19 cases of FPIES (12 with confirmed acute FPIES, 2 with confirmed chronic FPIES, 4 with presumptive acute FPIES, and 1 with chronic FPIES), patients reintroduced the food on their own, without any reaction, at a median age of 2.7 years (2.2-3.3).
For milk, the first OFC was performed at the median age of 1.8 years, which was earlier than for other foods (p<0.001), fish (p<0.001), meat and vegetables/legumes/fruits (p<0.01), but not different from hen’s egg and rice (Table II).
Eighteen OFCs were still not performed, because patients were too young and/or their last reaction was too recent and/or because of family refusal. Nine children were lost in the follow-up, including 6 without the performance of any OFCs, and 3 after one attempt at an OFC.