Results
In the 192 described FPIES, the age at first symptoms was 5.8 months
old. The main offending foods were cow’s milk (60.3%), hen’s egg
(16.2%), and fish (11.7%). Single FPIES was observed in 94.4% and
multiple FPIES in 5.6% of cases. The age at resolution of FPIES was 2.2
years old, and resolution occurred later for fish than for milk (2.9
years versus 2.0, p=0.01). Severe
acute FPIES was a risk factor for delayed resolution (relative risk: 3.3
[1.2-9.2]), but not IgE sensitization. Performing an oral food
challenge within 12 months after the first reaction increased the risk
of failure (RR: 2.0 [1.2-3.5]).