IgE sensitization
IgE sensitization to the culprit food was found in 28/180 FPIES
(14.7%). Skin prick tests with the offending food were performed in
121/192 cases (63.0%) and were positive in 5 cases (4.1%). One child
developed an IgE-mediated allergy with the culprit food over time: she
had a confirmed typical FPIES to CM until the age of 3 without any
sensitization, and had thereafter developed an immediate urticaria and
rhinoconjunctivitis after ingestion of CM at 5 years old, with a
positive SPT and increased CM’s IgE: 10.9 kU/L. By contrast, a child
with a history of IgE-mediated allergy to CM during the first year of
life (urticaria after cow’s milk ingestion and specific CM’s IgE: 4.9
kU/L at the age of 1 month), switched to FPIES to CM after 9 months of
age. Her specific IgE was negative at this time, and she had repetitive
vomiting, without skin or respiratory symptoms, during an OFC to CM at
the age of 10 months.