Abstract
Since the start of the coronavirus SARS-Cov-2 pandemic, a disease that
has become one of the world’s greatest global health challenges, the
role of the immune system has been at the forefront of scientific
studies. The pathophysiology of COVID-19 is complex, which is evident in
those at higher risk for poor outcome. Multiple systems contribute to
thrombosis and inflammation seen in COVID-19 patients, including
neutrophil and platelet activation, and endothelial dysfunction.
Understanding how the immune system functions in different patient
cohorts (particularly given recent emerging events with the
Oxford/AstraZeneca vaccine) is vital to understanding the
pathophysiology of this devastating disease and for the subsequent
development of novel therapeutic targets and to facilitate possible drug
repurposing strategies that could benefit society on a global scale.
Keywords: Thrombosis, inflammation, thromboinflammation,
neutrophils, platelets, resolution pharmacology