Author contributions
M.N, S.S, and Z.S designed and performed the experiments, analyzed data, and drafted the manuscript. W. P and C.Z. performed a part of the animal experiments. L.W, L.L, and Y.D performed a part of the in vitroexperiments. W.C, Q. G, and H.W conceived the projects, designed the experiments, analyzed data, and wrote the manuscript. All authors read and approved the final manuscript.