BET pharmacokinetic parameter
Singleton pregnancies (n=9) MC twin pregnancies (n=8) DC twin pregnancies (n=9)
p-value
Cmax (ng/mL)
55.35 (36.48- 70.96) 52.34 (40.07 – 63.61) 44.87 (29.44 – 56.82)
0.5299
tmax (h)
2.06 (1.03 – 2.90) 1,5 (0.86 – 2.01) 1.80 (0.83 – 2.52)
0.5665
AUC0-∞ (ng.h/mL)
670.0 (504.3 – 825.2) 494.9 (355.4 – 624.1) 434.9 (311.2 -539.6)
0.0345
CL/F (L/h)
18.38 (13.84 – 22.65) 25.46 (18.30 – 32.13) 29.4 (21.17 – 36.69)
0.0324
Vd/F (L)
226.1 (112.7 – 316.9) 265.4 (172.0 – 353.6) 279.9 (159.6 – 389.6)
0.6746
BET transplacental transfer
Singleton pregnancies (n=1) MC twin (n=1) DC twin (n=6a)
Drug administration and delivery interval (h)
20.34
6.04
2.02 (1.53 – 2.62)
Umbilical vein/Maternal vein ratio
0.33
0.20
0.15 (0.09 – 0.25)
Intervillous space /Maternal vein ratio
0.54
0.31
0.22 (0.07 – 0.60)