Cmax (ng/mL)
|
55.35
(36.48- 70.96)
|
52.34
(40.07 – 63.61)
|
44.87
(29.44 – 56.82)
|
0.5299
|
tmax (h)
|
2.06
(1.03 – 2.90)
|
1,5
(0.86 – 2.01)
|
1.80
(0.83 – 2.52)
|
0.5665
|
AUC0-∞ (ng.h/mL)
|
670.0
(504.3 – 825.2)
|
494.9
(355.4 – 624.1)
|
434.9
(311.2 -539.6)
|
0.0345
|
CL/F (L/h)
|
18.38
(13.84 – 22.65)
|
25.46
(18.30 – 32.13)
|
29.4
(21.17 – 36.69)
|
0.0324
|
Vd/F (L)
|
226.1
(112.7 – 316.9)
|
265.4
(172.0 – 353.6)
|
279.9
(159.6 – 389.6)
|
0.6746
|
BET transplacental transfer
|
Singleton pregnancies
(n=1)
|
MC twin
(n=1)
|
DC twin
(n=6a)
|
|
Drug administration and delivery interval (h)
|
20.34
|
6.04
|
2.02
(1.53 – 2.62)
|
|
Umbilical vein/Maternal vein ratio
|
0.33
|
0.20
|
0.15
(0.09 – 0.25)
|
|
Intervillous space /Maternal vein ratio
|
0.54
|
0.31
|
0.22
(0.07 – 0.60)
|
|