Figures legends:
Figure 1 – Plasma concentration versus time of betamethasone
in singleton pregnancies (n=9; circles), monochorionic (MC) twin
pregnancies (n=8; squares) and dichorionic (DC) twin pregnancies (n=9;
triangles) after a single dose of 6mg of betamethasone acetate plus 6mg
betamethasone phosphate. Values are expressed as geometric mean (95%
confidence interval).
Figure 2 – Correlation
between betamethasone apparent volume of distribution (Vd/F) and body
mass index (BMI) (p=0.02; r=0.4530). Data are presented individually.
Singleton pregnancies (n=8) are represented as full circles,
monochorionic (MC) twin pregnancies (n=9) are represented as open
circles and dichorionic (DC) twin pregnancies (n=9) are represented as
grey circles.
Figure 3 – Betamethasone concentration in the transplacental
transfer. Singleton pregnancies (n=1) are represented as circles,
monochorionic (MC) twin pregnancies (n=1) are represented as squares and
dichorionic (DC) twin pregnancies (n=3) are represented as hexagons.
Values are expressed as individual data. Symbols with a dot inside
represent maternal vein concentrations; Symbols with an “x” inside
represent intervillous space concentrations; Semi-full symbols represent
umbilical vein concentrations; Open symbols represent intervillous space
to maternal vein ratios, and solid symbols represent umbilical vein to
maternal vein ratios.