Statistical analysis
Data was analyzed by GraphPad Prism software (CA, USA). The BET pharmacokinetics data are presented as median and interquartile range. Pharmacokinetic parameters presented a normal distribution (Shapiro-Wilk test; p-value<0.05) so they were compared using ANOVA’s test with Tukey’s multiple comparisons test (p-value<0.05).26,27 Correlations between clinical features and pharmacokinetic parameters were analyzed using Pearson’s correlation (p-value <0.05).