Multiparametric MRI Multiparametric MRI Multiparametric MRI Multiparametric MRI 68(Ga) - PSMA PET/MRI 68(Ga) - PSMA PET/MRI 68(Ga) - PSMA PET/MRI 68(Ga) - PSMA PET/MRI Combined Imaging Combined Imaging Combined Imaging Combined Imaging
SEN (%) SPE (%) AUC (CI %95)
p
SEN (%) SPE (%) AUC (CI %95)
p
SEN (%) SPE (%) AUC (CI %95)
p
SUVmax
< 7.1
52,6
95,6
0,73 (0,64-0,82)
0,83
≥ 7.1
72,5
92,6
0,74 (0,64-0,85)
Total PSA (ng/ml)
<10
49,2
90,7
0,69 (0,61-0,78)
0,09
60
96,3
0,78 (0,70-0,86)
0,81
72,3
88,8
0,80 (0,73-0,87)
0,41
≥10
68,8
94,2
0,81 (0,71-0,92)
62,5
90,4
0,76 (0,65-0,87)
84,4
86,5
0,85(0,76-0,94)
PSAD (ng/ml/m)
< 0,18
50,9
88,9
0,70 (0,61-0,79)
0,22
54,5
95,1
0,75 (0,66-0,83)
0,32
74,5
85,2
0,80 (0,72-0,88)
0,40
≥ 0,18
61,9
94,9
0,78 (0,69-0,88)
69,0
93,6
0,81 (0,72-0,91)
78,6
91,0
0,85 (0,77-0,93)
PI-RADS score
≤ 3
34,5
94,9
0,64 (0,50-0,70)
0,10
55,2
94,9
0,75 (0,63-0,88)
0,62
65,5
89,7
0,78 (0,66-0,90)
0,34
≥ 4
64,7
90,8
0,77 (0,70-0,85)
63,2
94,2
0,79 (0,71-0,86)
80,0
87,5
0,84 (0,78-0,91)
Lesion volume(ml)
<1.5
54,5
92,5
0,74 (0,64-0,84)
0,96
54,5
96,3
0,75 (0,66-0,85)
0,56
77,3
88,8
0,83 (0,75-0,91)
0,78
≥1.5
56,6
91,1
0,74 (0,65-0,83)
66,0
92,4
0,79 (0,71-0,88)
75,5
87,3
0,81 (0,73-0,89)
Lesion length(mm)
<15mm
54,5
94,8
0,74 (0,65-0,83)
0,71
54,5
95,9
0,75 (0,66-0,84)
0,42
74,5
90,7
0,83 (0,75-0,90)
0,81
≥15mm
57,1
87,1
0,72 (0,61-0,82)
69,0
91,9
0,81 (0,71-0,90)
78,6
83,9
0,81 (0,72-0,90)
Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval Abbreviations. MRI: magnetic resonance imaging, 68(Ga): Galium-68, PSMA: prostate specific membrane antigen PET: positron emission tomography, SUVmax : maximum standardised uptake value, PSA: prostate specific antigen, SEN: sensitivity, SPE: specificity, AUC: area under curve, ROC: Receiver operating characteristic, CI: confidence interval