LIST OF SUPPLEMENTARY MATERIAL
- Fig. S1. Effects of deficiency in cortistatin in liver histology of naïve, sham-operated and vehicle-treated mice.
- Fig. S2. Histopathological sings of exacerbated hepatic fibrosis in cortistatin-deficient mice.
- Fig. S3. Lung pathology accompanied exacerbated hepatic fibrosis in cortistatin-deficient mice.
- Fig. S4. Cortistatin-deficient hepatic stellate cells (HSCs) show exacerbated myofibroblastic responses.
- Fig. S5. Cortistatin regulates activation of human HSC LX2line.
- Fig. S6. Treatment with cortistatin reversed the exacerbated toxic-induced liver fibrosis observed in cortistatin-deficient mice.
- Fig. S7. Exogenous administration of cortistatin protects from cholestatic-induced hepatic fibrosis.
- Table S1. List of muscle-related genes found within the Top-25 upregulated differentially expressed genes (DEGs) inCST-/- HSCs (ordered by fold-change expression).
- Tables S2. Annotated differentially expressed genes (DEGs) in Gene Ontology (GO) terms for Cellular Components forCST-/- HSCs versusCST+/+ HSCs.
Tables S3. Annotated differentially expressed genes (DEGs) in Gene Ontology (GO) terms for Body Processes forCST-/- HSCs versusCST+/+ HSCs.
Tables S4. Annotated differentially expressed genes (DEGs) in Gene Ontology (GO) terms for Molecular Functions forCST-/- HSCs versusCST+/+ HSCs.
- Table S5. Annotated differentially expressed genes (DEGs) in Gene Ontology (GO) terms for Molecular Functions for CST-/-HSCs versus CST+/+ HSCs.
- Table S6. Antibodies used in the study.
- Table S7. Primer sequences for real-time qPCR analysis.
- Supplementary References.