Naltrexone
Three RCTs[30, 32, 33] involving 432 smokers reported the smoking cessation effects of Naltrexone. The results of the subgroup analysis showed that, for two studies after eight weeks of treatment, there were no statistically significant differences in smoking cessation rates between the treatment and control groups (OR = 0.99, 95% CI: [0.54, 1.81], p = 0.97), nor were there any significant differences in a single study after 2, 12, 16, or 26 weeks (figure 4) of treatment. The overall effect size indicated Naltrexone did not significantly increase the smoking cessation rate of alcohol-dependent people.