Naltrexone
Three RCTs[30, 32, 33] involving 432 smokers reported the smoking
cessation effects of Naltrexone. The results of the subgroup analysis
showed that, for two studies after eight weeks of treatment, there were
no statistically significant differences in smoking cessation rates
between the treatment and control groups (OR = 0.99, 95% CI: [0.54,
1.81], p = 0.97), nor were there any significant differences in
a single study after 2, 12, 16, or 26 weeks (figure 4) of treatment. The
overall effect size indicated Naltrexone did not significantly increase
the smoking cessation rate of alcohol-dependent people.