Conclusion
Based on the analysis of the studies included in this systematic review and meta-analysis, Varenicline may have a positive effect on smoking cessation in people with alcohol dependence in the short-term. However, Naltrexone, Topiramate, and Bupropion appear to have no clear effect on increasing smoking abstinence among drinkers. In particular, the small number of studies and low certainty of evidence have increased the uncertainty of the results. Therefore, in order to produce long-term and extensive evidence, more studies are needed to support these conclusions.