Conclusions
Early activation of MPP was not associated to an advantage increasing
echocardiography responders to CRT at 6 months of follow up.
Nevertheless, MPP was associated to a low incidence of negative
responders to CRT according to clinical composite score. Similar to
previous studies, it was observed a higher CRT response rate and a
higher improvement in left ventricular function at 6 months in subjects
programmed using widest pacing cathodes. Finally, MPP in this study was
associated with a low incidence of mortality and hospital admissions at
6 months of follow-up, which were significantly lower than those
observed with conventional biventricular pacing in a comparative
historical cohort of patients.
Ethical approval : All procedures performed in studies involving
human participants were in accordance with the ethical standards of the
institutional and/or national research committee and with the 1964
Helsinki declaration and its later amendments or comparable ethical
standards. Abbott provided funding for the study. The ClinicalTrials.gov
Identifier is NCT02476201.
Informed consent : Informed consent was obtained from all
individual participants included in the study.