Conclusions
Early activation of MPP was not associated to an advantage increasing echocardiography responders to CRT at 6 months of follow up. Nevertheless, MPP was associated to a low incidence of negative responders to CRT according to clinical composite score. Similar to previous studies, it was observed a higher CRT response rate and a higher improvement in left ventricular function at 6 months in subjects programmed using widest pacing cathodes. Finally, MPP in this study was associated with a low incidence of mortality and hospital admissions at 6 months of follow-up, which were significantly lower than those observed with conventional biventricular pacing in a comparative historical cohort of patients.
Ethical approval : All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Abbott provided funding for the study. The ClinicalTrials.gov Identifier is NCT02476201.
Informed consent : Informed consent was obtained from all individual participants included in the study.