3. Results and Discussion
A lab-on-chip approach was used to test the hypothesis that loss of
Panx1 function alters an experimental PD phenotype. To investigate this
hypothesis, 2dpf panx1a+/+ andpanx1a-/- larvae were exposed to 250µM 6-OHDA
for either 72 or 120hrs. The research compared behavioral responses and
changes of TH expression of panx1a+/+ andpanx1a-/- larvae exposed to 6-OHDA with the
non-treated control groups.