3.3. Effect of D1- and D2-like selective antagonists and agonists on zebrafish response to electricity
After showing the effect of non-selective DA compounds on the electric-induced response of zebrafish larvae, we assessed potential roles of specific DA receptors in regulating this response.
We first assessed the effect of SKF-81297 (a D1-like selective agonist) alone and observed no significant effect on the electric-induced RD and TBF of zebrafish larvae (Fig. 4). In contrast, the response of larvae exposed to SCH-23390 (a D1-like selective antagonist) was marked by a shorter RD and TBF with values decreasing by 48% and 27%, respectively (P-value<0.001 and 0.05, respectively). In zebrafish larvae exposed to SCH-23390, we observed no significant change upon post treatment with SKF-81297.