Patient Population
The study is a retrospective chart review of consecutive patients
treated for Acute Lymphoblastic Leukemia at the CCI. Children and
adolescents aged 1-21 years who were diagnosed between October 2007 and
February 2018 were included. Patients who developed CSVT during
treatment were identified. Relevant information such as patient
characteristics, treatment regimen and clinical outcome were collected
and compared between two groups: patients who developed CSVT during
treatment versus those who did not. CT venography and/ or MRI were used
to diagnose CSVT.
This study builds on a previous one done at our institution that
described certain potential risk factors for the development of CSVT in
children being treated for ALL. It showed that age above 10 years at
diagnosis, T-cell immunophenotype and risk stratification
(intermediate/high risk) were statistically significant risk factors for
CSVT [4].
Our study was reviewed and approved by the Institutional Review Board at
the American University of Beirut Medical Center.