Thrombophilia Screening
All patients who developed CSVT underwent screening for inherited
thrombophilia via Strip Assay (Reverse Hybridization-SSOP) to look for
factor V Leiden (G1691A), factor V (H1299R), MTHFR (C677T), MTHFR
(A1298C), and factor II (G20210A).
Due to the lack of solid evidence for screening all children during ALL
therapy for inherited thrombophilia, only patients who developed CSVT
underwent the above screening.
Triglyceride levels were measured before each asparaginase dose.