Structural Variant (SV) types and how they differ from a reference genome: A) deletion, where a segment of DNA is not present in an individual, but present in the reference; B) duplication, a rearrangement where there is more than one copy of a particular region of the genome, often in tandem. These can be either intrachromosomal, as shown here, or interchromosomal; C) insertion, a DNA sequence present in an individual sample, but not present in the reference; D) inversion, a segment of the chromosome that has had a double-stranded break at an upstream and downstream location and become reversed in order; E) translocation, a rearrangement where a portion of one chromosome has been transposed onto another.