Patients Clinical Characteristics
This study included 81 patients diagnosed with NB between March 2005 and March 2019. Three patients have been discarded from the analysis due to lack of data regarding MYCN status. Of the remaining 78, 50 were male and 28 female, with a median age at diagnosis of 28 months (range 14 days-199 months). Table 1 summarizes the characteristics of patients. Patients were divided in three categories according to MYCN gene amplification: amplified (24), not amplified (43) and gain (11). Both a three (amplified versus not amplified versus gain) and a two variables (amplified plus gain versus not amplified) analysis were performed in order to test model’s performance. At the time of the analysis, mean OS was 47 months (range: 17-171).