Declarations of interest

The studies were funded by grants from the Swedish Research Council and the Asthma and Allergy Association. The first author has received grants from Hesselman’s Research Foundation and ACTA Otolaryngologica.

Registration in public trials registry

ILIT after SCIT-10 000 was registered at ClinicalTrials.gov with ID NCT02679105. ILIT de novo- 3000 was registered at ClinicalTrials.gov with ID NCT02975479.

Abbreviations

AR Allergic rhinitis
AIT Allergy immunotherapy
AUC Area under the curve
CSMS Combined symptoms and medication score
CM Central memory cell
DC Dendritic cell
EM Effector memory cell
GAM Generalized Additive Model
ILIT Intralymphatic immunotherapy
MFI Median fluorescence intensity
MS Medication score
NPT Nasal provocation test
PBL Peripheral blood
RR Relative risk
RQLQ Rhinoconjunctivitis quality of life questionnaire
RDBPC Randomized double-blind placebo-controlled
SCIT Subcutaneous immunotherapy
SPT Skin prick test
SS Symptom score
Th cell T helper cell
Treg cell T regulatory cell
VAS Visual analogue scale
QoL Quality of life