STUDY LIMITATIONS
Our study has several limitations with a single center and small patient
group. Because of our small amount of patients, the study had only 9
indeterminate patients, so we could not demonstrate whether LV GLS is
adequate to define diastolic dysfunction in those patient groups.
Besides, all standard echocardiographic measurements and LV GLS were
performed in resting, so we could not assess the relationship between LV
GLS and impaired functional capacity, which is the highly essential
hallmark for HFpEF. Future studies with a multicenter design and a
larger study population will be essential to demonstrate the additional
effects of GLS on the 2016 ASE/EACVI algorithm as well as on the
HFA-PEFF algorithm