|
t1/2 (h)
|
tmax (h)
|
Vd (L/ng)
|
CL
(mL/h*ng)
|
Cmax (ng/mL)
|
AUC(0→96)
(h*ng/mL)
|
BUP PK |
|
|
|
|
|
|
Fasting CYP2B6*1/*1 (n=10) |
11.51±3.69 |
2.40±0.97 |
3.501±0.752 |
219.46±54.05 |
74.58±19.65 |
716.99±182.70 |
Fasting CYP2B6 mutants (n=10) |
14.64±4.18 |
2.20±0.63 |
4.254±1.035 |
208.79±55.99 |
84.92±18.26 |
744.48±159.49 |
P |
0.093 |
0.591 |
0.079 |
0.670 |
0.239 |
0.724 |
HBUP PK |
|
|
|
|
|
|
Fasting CYP2B6*1/*1 (n=10) |
19.75±3.79 |
6.30±1.70 |
0.830±0.140 |
30.64±10.08 |
125.64±24.74 |
5081.26±1479.82 |
Fasting CYP2B6 mutants (n=10) |
23.53±4.73 |
6.60±1.78 |
0.943±0.277 |
28.54±9.41 |
134.45±54.68 |
5542.37±2244.70 |
P |
0.064 |
0.704 |
0.265 |
0.637 |
0.648 |
0.594 |