t1/2 (h) tmax (h) Vd (L/ng) CL (mL/h*ng) Cmax (ng/mL) AUC(0→96) (h*ng/mL)
BUP PK
Feeding CYP2B6*1/*1 (n=11) 15.95±5.68 2.91±1.41 4.310±2.165 185.16±39.62 98.92±22.62 828.97±179.94
Feeding CYP2B6 mutants (n=13) 14.69±3.94 3.54±1.23 3.906±0.803 190.34±42.87 90.05±21.95 807.16±153.53
P 0.529 0.256 0.538 0.763 0.341 0.752
HBUP PK
Feeding CYP2B6*1/*1 (n=11) 21.89±3.54 6.86±2.61 0.601±0.105 19.30±3.72 180.82±38.68 7555.68±1399.58
Feeding CYP2B6 mutants (n=13) 22.14±3.84 6.46±2.29 0.889±0.525 29.45±20.78 165.57±105.56 7129.85±4389.42
P 0.870 0.692 0.087 0.434 0.155 0.311