|
t1/2 (h)
|
tmax (h)
|
Vd (L/ng)
|
CL
(mL/h*ng)
|
Cmax (ng/mL)
|
AUC(0→96)
(h*ng/mL)
|
BUP PK |
|
|
|
|
|
|
Fasting CYP2B6 mutants (n=10) |
14.64±4.18 |
2.20±0.63 |
4.254±1.035 |
208.79±55.99 |
84.92±18.26 |
744.48±159.49 |
Feeding CYP2B6 mutants (n=13) |
14.69±3.94 |
3.54±1.23 |
3.906±0.803 |
190.34±42.87 |
90.05±21.95 |
807.16±153.53 |
P |
0.975 |
0.010*
|
0.374 |
0.380 |
0.558 |
0.351 |
HBUP PK |
|
|
|
|
|
|
Fasting CYP2B6 mutants (n=10) |
23.53±4.73 |
6.60±1.78 |
0.943±0.277 |
28.5±9.41 |
134.45±54.68 |
5542.37±2244.70 |
Feeding CYP2B6 mutants (n=13) |
22.14±3.84 |
6.46±2.29 |
0.889±0.525 |
29.45±20.78 |
165.57±105.56 |
7129.85±4389.42 |
P |
0.444 |
0.876 |
0.770 |
0.899 |
0.407 |
0.310 |