t1/2 (h) tmax (h) Vd (L/ng) CL (mL/h*ng) Cmax (ng/mL) AUC(0→96) (h*ng/mL)
BUP PK
Fasting CYP2B6 mutants (n=10) 14.64±4.18 2.20±0.63 4.254±1.035 208.79±55.99 84.92±18.26 744.48±159.49
Feeding CYP2B6 mutants (n=13) 14.69±3.94 3.54±1.23 3.906±0.803 190.34±42.87 90.05±21.95 807.16±153.53
P 0.975 0.010* 0.374 0.380 0.558 0.351
HBUP PK
Fasting CYP2B6 mutants (n=10) 23.53±4.73 6.60±1.78 0.943±0.277 28.5±9.41 134.45±54.68 5542.37±2244.70
Feeding CYP2B6 mutants (n=13) 22.14±3.84 6.46±2.29 0.889±0.525 29.45±20.78 165.57±105.56 7129.85±4389.42
P 0.444 0.876 0.770 0.899 0.407 0.310