Funding
This work was supported by National Natural Science Foundation of China (Grant No. 81772760, 82072850), The Shandong Taishan Scholarship (NO. tsqn20161076), The Innovation Project of Shandong Academy of Medical Sciences (2021), The Youth Innovation Technology Plan of Shandong University (2019KJK003) and Academic promotion programme of Shandong First Medical University (LJ001).