Serological quantitative analysis confirmed Lep, Cer, and DHCer as maternal markers for PE at diagnosis
We measured levels of circulating Lep in women from the testing cohort (testing cohort included 7 non-PE and 8 PE women; demographic data are shown in Table II). Concentrations of Lep were significantly higher in PE women than in women without PE between 25 and 31 wks’ of gestation (P = 0.02, 2.97-fold; Fig. 4A, Appendices 2 and 3).
We also characterized gestational profiles of 16 Cers and 10 DHCers in maternal sera (Fig. 4, Appendices 2 and 3). A total of 11 candidates (4 Cers and 7 DHCers) were significantly altered in PE (P< 0.05; Fig. 4A). Among the 11 candidates, Cer (d18:1/25:0) was found to be the only Cer that significantly changed compared with Lep in PE women (0.88-fold).