Exposure in late pregnancy and late-onset preeclampsia
Table 3 shows the results for the use of calcium-based antacids and PPIs
after gestational week 33. No associations were observed between any
calcium-based antacid use (adjusted HR 1.0 [95% CI 0.6-1.5]) or PPI
use (adjusted HR 1.4 [95% CI 0.7-2.9]) and late-onset preeclampsia.
Using a high dose of PPIs after gestational week 33 seemed to increase
the risk of late-onset preeclampsia (crude HR 2.7 [95% CI
0.9-8.5]), but this observation was based on a small number of exposed
pregnancies (N=55).