Main findings
In this prospective cohort study, we did not observe decreased risks of
late-onset preeclampsia after use of calcium-based antacids or PPIs
during pregnancy, irrespective of the timing of use. In contrast, low
dose calcium-based antacid use in gestational weeks 0-16 and any PPI use
in gestational weeks 17-33 were associated with a modestly increased
risk of late-onset preeclampsia.