Figure 1: Influence of NT5E/CD73 5’UTR polymorphism (rs2295890)
in F-araA PK.
Association between rs2295890 genotype and post-hoc PK estimates- F-ara
AUC (A) and Clearance (B). *Wt- Homozygous reference genotype, Het/Mut-
Heterozygous and homozygous genotype, p-value was calculated by Mann
Whitney U Test. Patients harboring NT5E promoter variant genotype
exhibited significantly lower plasma F-araA CL and higher AUC compared
to those with wild-type genotype.