Parameter Base RSE (%) rs2295890 RSE (%) p-value
CL (L/h/m2) 6.87 4.8 7.17 5.2
β: CL* -0.29 43.3 0.02
V (L/m2) 18.74 4.5 18.55 4.7
Q (L/h/m2) 14.21 0.2 14.46 0.2
V2 (L/m2) 25.67 1.3 25.99 1.8
σ additive (µM) 0.06 20.0 0.06 15.4
σ prop CV%)
0.10
4.1
0.10
6.3
-2 Log-likelihoodb 1750.2 1739.5 0.001
IIV (CV%) RSE (%) (CV%) RSE (%)
CL 0.57 6.6 0.56 6.8
V 0.33 21.2 0.34 19.8
Q 0.70 11.8 0.71 9.1
V2 0.40 12.8 0.44 13.5