Patient Demographics
Between November 2010 and 2019, 281 patients with TM underwent HCT in
our centre. Of these, patients who gave consent to participate in the
study, as well as those with follow-up, were enrolled for the PK study
(n=169). There was no significant difference in demographics between the
patients with high-risk TM enrolled in the PK study compared to the
total number of patients with high-risk TM who underwent HCT during the
study period. (Table-S2) Two hundred and eighty-one patients with
high-risk TM underwent HCT with Thio/F-araA/Treo conditioning regimen
during the study period. Their median age was 9yrs (1-25yrs). Majority
of the patients belonged to class III (Class III High Risk-48%; class
III Low risk-39%) and 12% of patients belonged to class II. The
demographics of these patients are summarized in Table 1.