S.No Diagnosis N Conditioning regimen Flu Dose Donor type AUC (uM*h) Median(range) CL (L/h/m2) Median (range) Reference
1
CML-04 & MDS-38
42
Flu : 4 days & Oral Bu : 4 days
30mg/m2/day
MRD-16 MUD-26
Mean + SD (Range) 19.1+7 (8.0-45.2) Mean + SD (Range) 6.3+2.4 (2.2-13.3)
29
2
AML-05, MF-05, CML-01 CMML- 01 & MDS- 03 AML/MDS- 01
16
Flu: day -6 to -3 & Bu: day -5 to -2
30mg/m2/day
-
21.03 (10.17-38.56) 5.04 (2.7-10.2)
6
3
ALL-06, AML-26, NHL-17, MDS-14, HL-08, CML-01 & Othersa-15
87
Flu: days -6 to -2 & Cy: day-6
40mg/m2/day (N=78) or 30-35mg/m2/day (N=9)
MRD-22 MUD-65
40mg/m2: 17.19 (7.02-40.35) 30-35mg/m2 19.29 (15.1-24.56) 40mg/m2: 16.0 (6.2–36.6)L/h 30-35mg/m2: 11.5 (6.9–15.2) L/h
7
4
AML-05, CML-01, MDS-04, MF-05 & CMML-01
16
Flu: days -6 to -2; targeted daily IV Bu days -5 to -2 & rATG on days -3 to -1
50 mg/m2 /day
MRD-11 MUD-05
24.8 (16.3-39.9)
-
30
5
-05, HL-03 & /-03
11
Flu: days −6 to −2; Cy: days −6 and −5 & TBI day −1
30mg/m2/day
Haplo-11
16.4 (10.4 – 21.5)
-
31
6
MDS-18, AML-13, CML-05, CMML-02 & MF-03
41
Protocol 1519 (N=27) Flu: days -9 to -6; targeted oral Bu days -5 to -2 Protocol 2041 (N=14) Flu: days -6 to -2, targeted daily IV Bu on days -5 to -2, and rATG IV on day -3, to -1 30 mg/m2/day 50 mg/m2/day
-
-
Protocol 1519: 9.1 (8-45.2) Protocol 2041: 7.07 (4.40-10.76)
32
7
NHL-34, CLL-22, AML-15, MDS-10, MM-09, ALL- 04, MF- 03, AA- 02 HL- 02 & PNH - 01
102
Flu: days -4 to -2 & 2-4.5 Gy TBI
30 mg/m2/day
MRD-24 MUD-78
Mean + SD (Range) 19.6±4.8 (10–36.4)
-
33
8
AA – 40 & FA-13
53
Flu: days -6 to -2 & Cy: days -3 & -2
30mg/m2/day
MSD-45 AD-08
20 (4-53)
4.7 (1.2-22.4)
9
9
HM-59, PID-18, HP-8, IMD-22, BMF-22 & EB-4
133
Bu/Flu Cy/Flu Bu/Flu/Clo Flu/ThioT/Mel Others 40 mg/m2/day 12.5-35mg/m2/day 0.9 - 1.33 mg/kg MRD-38 MUD-95 13 (11.5-15.7)
3.3 (L/h/15kg)
10
10
AL-29, JMML/ALCL-2, SAA-3, CGD-3 OS-2 & Othersa-4
43
Flu: day −8 to day −3 & Bu: day −8, targeted Bu from day -7 to −5
40 mg/m2/day
MRD-6 MUD-34 Haplo- 3 15 (10.1-30.6)
6.47
34
11
BD-69 L-117 LY-17 MDS-32 PCD-23
258
Bu/Flu: day − 5 to day – 2 Bu/Flu/Clo in children with malignancies rATG in MUD (day − 9 for children, and−12 (for adults)
40 mg/m2/day
-
Children 18.4 (5-36.8) Adults 22.8 (11.4-57)
3.2 (L/h/)
11
12
TM
169b
Flu: day -5 to -2 Treo: day -5 to -3 ThioT on day -6
40mg/m2/day
MSD-152 MRD- 11 MUD- 29
19 (3-81)
7 (2-38)
Present Study