1
|
CML-04 &
MDS-38
|
42
|
Flu : 4 days &
Oral Bu : 4 days
|
30mg/m2/day
|
MRD-16 MUD-26
|
Mean + SD (Range)
19.1+7
(8.0-45.2)
|
Mean + SD (Range)
6.3+2.4
(2.2-13.3)
|
29
|
2
|
AML-05,
MF-05,
CML-01
CMML- 01 &
MDS- 03
AML/MDS- 01
|
16
|
Flu: day -6 to -3 &
Bu: day -5 to -2
|
30mg/m2/day
|
-
|
21.03
(10.17-38.56)
|
5.04
(2.7-10.2)
|
6
|
3
|
ALL-06,
AML-26,
NHL-17,
MDS-14,
HL-08,
CML-01 &
Othersa-15
|
87
|
Flu: days -6 to -2 & Cy: day-6
|
40mg/m2/day (N=78)
or
30-35mg/m2/day (N=9)
|
MRD-22 MUD-65
|
40mg/m2:
17.19
(7.02-40.35)
30-35mg/m2
19.29
(15.1-24.56)
|
40mg/m2:
16.0 (6.2–36.6)L/h
30-35mg/m2:
11.5 (6.9–15.2) L/h
|
7
|
4
|
AML-05,
CML-01,
MDS-04,
MF-05 &
CMML-01
|
16
|
Flu: days -6 to -2; targeted daily IV Bu days -5 to -2 &
rATG on days -3 to -1
|
50 mg/m2 /day
|
MRD-11 MUD-05
|
24.8
(16.3-39.9)
|
-
|
30
|
5
|
-05,
HL-03
& /-03
|
11
|
Flu: days −6 to −2; Cy: days −6 and −5 & TBI day −1
|
30mg/m2/day
|
Haplo-11
|
16.4
(10.4 – 21.5)
|
-
|
31
|
6
|
MDS-18,
AML-13,
CML-05,
CMML-02 &
MF-03
|
41
|
Protocol 1519 (N=27) Flu: days -9 to -6; targeted oral Bu days -5 to -2
Protocol 2041 (N=14) Flu: days -6 to -2, targeted daily IV Bu on days -5
to -2, and rATG IV on day -3, to -1
|
30 mg/m2/day
50 mg/m2/day
|
-
|
-
|
Protocol 1519:
9.1 (8-45.2)
Protocol 2041: 7.07 (4.40-10.76)
|
32
|
7
|
NHL-34,
CLL-22,
AML-15,
MDS-10,
MM-09,
ALL- 04,
MF- 03,
AA- 02
HL- 02 &
PNH - 01
|
102
|
Flu: days -4 to -2
&
2-4.5 Gy TBI
|
30 mg/m2/day
|
MRD-24 MUD-78
|
Mean + SD (Range)
19.6±4.8
(10–36.4)
|
-
|
33
|
8
|
AA – 40 &
FA-13
|
53
|
Flu: days -6 to -2 & Cy: days -3 & -2
|
30mg/m2/day
|
MSD-45 AD-08
|
20
(4-53)
|
4.7 (1.2-22.4)
|
9
|
9
|
HM-59,
PID-18,
HP-8,
IMD-22,
BMF-22 &
EB-4
|
133
|
Bu/Flu
Cy/Flu
Bu/Flu/Clo
Flu/ThioT/Mel
Others
|
40 mg/m2/day
12.5-35mg/m2/day
0.9 - 1.33 mg/kg
|
MRD-38
MUD-95
|
13
(11.5-15.7)
|
3.3 (L/h/15kg)
|
10
|
10
|
AL-29,
JMML/ALCL-2,
SAA-3,
CGD-3
OS-2 &
Othersa-4
|
43
|
Flu: day −8 to day −3 &
Bu: day −8, targeted Bu from day -7 to −5
|
40 mg/m2/day
|
MRD-6
MUD-34
Haplo- 3
|
15
(10.1-30.6)
|
6.47
|
34
|
11
|
BD-69
L-117
LY-17
MDS-32
PCD-23
|
258
|
Bu/Flu: day − 5 to day – 2
Bu/Flu/Clo in children with malignancies
rATG in MUD
(day − 9 for children, and−12 (for adults)
|
40 mg/m2/day
|
-
|
Children
18.4 (5-36.8)
Adults
22.8 (11.4-57)
|
3.2 (L/h/)
|
11
|
12
|
TM
|
169b
|
Flu: day -5 to -2 Treo: day -5 to -3 ThioT on day -6
|
40mg/m2/day
|
MSD-152
MRD- 11
MUD- 29
|
19 (3-81)
|
7 (2-38)
|
Present Study
|