Results
The mean age of the 102 patients included in our study was 56.1 ± 14.9
percent. The mean age of the patients in the control group was 53.1 ±
18.1 percent. No statistically significant difference was observed
between the patient and the control group (p=0.34) 59 of the patients
were male and 43 were female. The mean age of male patients was 56.3 ±
15.8 and female patients were 55.9 ± 13.8 percent. Statistical analysis
of the mean age of patients by gender showed no significant difference
between average age (p=0.9).
While we did not have patients who developed mortality during the
follow-up, the need for mechanical ventilators in severe patients did
not occur in the following process. Only 2 severe pneumonia patients
developed a massive pulmonary thromboembolism setting in spite of the
application of enoxaparin sodium at 12-hour intervals in accordance with
weight.
Evaluation of laboratory parameters according to the disease severity
belonging to COVID-19 patients included in our study was carried out in
Table 1. NLR, LDH, prothrombin time, CRP, PaO2/FiO2, D-Dimer, ferritin
and fibrinogen levels which have been mentioned in previous studies to
have prognostic importance for COVID-19, were observed to be higher in
the severely ill group (p=0.001, 0.001, 0.05, 0.001, 0.001, 0.005,
0.001, 0.001 respectively). Comparison of the patient groups among
themselves and the control group with suPAR and KIM-1 levels is shown in
Table 2. Accordingly, suPAR and KIM-1 levels were statistically
significantly higher to the control group in patient groups (p=0.001 for
all). While suPAR level was statistically significantly lower in severe
patients compared to middle patients (p=0.034), KIM-1 level was observed
to be higher in severely ill patients (p=0.001).
Comparison of the suPAR and KIM-1 levels of patient groups among
themselves and the control group is shown in Table 2. Accordingly, suPAR
and KIM-1 levels were statistically significantly higher to the control
group in patient groups (p=0.001 for all). While suPAR level was
statistically significantly lower in severe patients compared to middle
patients (p=0.034), KIM-1 level was observed to be higher in severe
patients (p=0.001).
While negative directional correlation was observed in the correlation
analysis of suPAR level with age (r=-0.197, p=0.05), positive
directional correlation was observed in correlation analysis with
PaO2/FiO2 level (r=0.316, p=0.01) (Figure 1). Statistically significant
difference was not observed in the correlational analysis of suPAR level
with D-Dimer (r=-0, 114, p=0,255). While negative directional
correlation was observed in the correlation analysis of KIM-1 level with
PaO2/FiO2 level (Figure 1), it was observed that it showed positive
correlation with parameters associated with prognosis such as NLR and
LDH (r=-0,319, p=0.01, r=0.336, p=0.01, r=0.466, p=0.01 respectively).