Patient selection
This methodological study was conducted in Istanbul University, Faculty
of Medicine, Adult Immunology and Allergy Clinic. To be included in the
study, all of the following inclusion criteria had to be fulfilled:
>18 years, diagnosis of CVID more than 6 months, currently
receiving intravenous or subcutaneous immunoglobulin replacement
therapy. CVID was diagnosed according to the ESID
criteria23. Inability or unwillingness to give
informed consent and significant medical or psychiatric illness were the
exclusion criteria.