3.3 I2-IR ligand LSL60101 and donepezil ameliorate social
deficits presented by 5XFAD mice.
To evaluate the effect of treatments on social behaviour, the mice were
subjected to the TCT. No differences in the number of the entries to
each chamber were determined in the habituation phase in any tested
group (Figure 2g). In contrary mice spent more time in the intruder’s
chamber during the test phase in all experimental conditions (Figure
2h). When the social interaction was evaluated, 5XFAD mice spent
significantly less time interacting with the intruder when compared to
WT healthy control. All treatments improved social impairments in 5XFAD
treated groups by increasing the time of interaction compared to the
5XFAD controls, but only 5XFAD treated with donepezil reached
significance (Figure 2i), whereas for LSL60101 p<0.06 was
calculated. WT treated mice presented no differences compared to WT
controls.