Predictive values of FMD and VEGF for endothelial dysfunction in
mastocytosis
In the ROC curve analysis, less than 14.5% was determined as the
optimal cut-off value for FMD in mastocytosis patients with the
sensitivity, specificity, positive and negative predictive values of
75.5%, 76%, 84.4% and 62%, respectively (AUC:0.796, 95% CI:0.696 to
0.897, p<0.001). In 37 (75.5%) patients, FMD was less than
14.5%. Also, odds ratio (OR) was detected as 8.883 (%95 CI:
2.954-26.717). Higher than 62.7 pg/mL was selected as the optimal
cut-off value for VEGF in mastocytosis patients with 65.5% and 64%
sensitivity and specificity rates, respectively. Positive and negative
predictive values were 78.05% and 48.48%, respectively and OR was
3.346 (%95 CI:1.223-9.155).
The area under curve (AUC) in ROC analysis for FMD% was determined as
79.7% and standard error was determined 5.13%. For VEGF, AUC was
determined 72.9% and with 6.16 % standard error. Comparing these two
AUC values, there was no statistically significant difference in the
level of predicting the patients with mastocytosis who had endothelial
dysfunction. The cut-off values of FMD and VEGF, AUC, specificity and
sensitivity values were shown in Figure-2.