Predictive values of FMD and VEGF for endothelial dysfunction in mastocytosis
In the ROC curve analysis, less than 14.5% was determined as the optimal cut-off value for FMD in mastocytosis patients with the sensitivity, specificity, positive and negative predictive values of 75.5%, 76%, 84.4% and 62%, respectively (AUC:0.796, 95% CI:0.696 to 0.897, p<0.001). In 37 (75.5%) patients, FMD was less than 14.5%. Also, odds ratio (OR) was detected as 8.883 (%95 CI: 2.954-26.717). Higher than 62.7 pg/mL was selected as the optimal cut-off value for VEGF in mastocytosis patients with 65.5% and 64% sensitivity and specificity rates, respectively. Positive and negative predictive values were 78.05% and 48.48%, respectively and OR was 3.346 (%95 CI:1.223-9.155).
The area under curve (AUC) in ROC analysis for FMD% was determined as 79.7% and standard error was determined 5.13%. For VEGF, AUC was determined 72.9% and with 6.16 % standard error. Comparing these two AUC values, there was no statistically significant difference in the level of predicting the patients with mastocytosis who had endothelial dysfunction. The cut-off values of FMD and VEGF, AUC, specificity and sensitivity values were shown in Figure-2.