PMIS evaluation protocol
We used a three-stage evaluation protocol that was developed based on information available on PMIS at the end of May 2020 and deduced from Kawasaki’s syndrome. Children with strong antibody responses were asked to contact their caring pediatrician or, in cases when this was not possible, to approach study doctors being pediatric cardiologists and Kawasaki experts. The first stage of evaluation included clinical parameters: fever for three days or more, conjunctivitis, lymphadenopathy, exanthema, enanthema, skin pealing, oedema/ erythema of extremities, gastrointestinal problems, and arterial hypotension. The second stage comprised laboratory investigations such as urine examination for protein, leukocytes and erythrocytes and inflammatory markers in blood. At the third stage, screening for blood coagulopathies and cardiac effects (by echocardiography) were performed. The protocol used for this evaluation is accessible online (www.cokiba.we-care.de).