Statistical Analysis
Analyses were performed using SPSS Statistics v21.0 (IBM, Chicago, IL, USA). Not-normally distributed continuous data were expressed as median and interquartile ranges (IQR). Group comparisons were carried out using Mann–Whitney U-test or ANOVA as appropriate for the continuous, and the chi-square test or Fisher test for categorical variables. The correlation coefficients between clinical manifestations and other clinical variables were determined using Spearman‘s rank correlation or Pearsons coefficient. A P level <0.05 was considered significant.