Introduction
Cancers remain one of the main causes of long-term mortality after heart transplantation. According to the International Society of Heart and Lung Transplantation (ISHLT), 16% of the transplant recipients develop a cancer within five years and almost 30% within ten years (1,2). Among this population, 50% develop cutaneous cancers but lymphomas are frequent as well, representing 10% of these patients (2). Interestingly, the incidence of lymphoma does not regularly increase during follow-up but is more important during the 5 years following transplantation (3). Notably, post-cardiac transplant lymphomas are more likely extranodal with lesions of the central nervous system, lungs, or liver (3). However, isolated cardiac graft lymphomas are extremely unusual and have been poorly reported so far. We aimed at describing the case of a patient who developed an isolated graft lymphoma after receiving heart transplantation.