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\begin{document}

\title{BEST DRUG INTERACTION FOR COVID-19 THERAPEUTIC MANAGEMENT: A METANALYSIS}



\author[1]{Maria Gabriela Farias}%
\author[1]{Wesley Conceição}%
\author[2]{María Gutiérrez}%
\author[2]{Mariana Pereira}%
\author[1]{Carla Daltro}%
\author[1]{Roberto Silva}%
\affil[1]{Universidade Salvador}%
\affil[2]{Centro de Pesquisas Goncalo Moniz}%


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  \date{May 14, 2024}


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\begin{abstract}
Background and Purpose: The Covid-19 is a viral infection classified as
a pandemic by the World Health Organization. There is not currently
therapy against the Sars-cov-2. We aimed to assess the best drug therapy
approach for the management of Covid-19. Experimental Approach: We did a
systematic review and meta-analysis of randomized controlled trials of
drugs used in patients with Covid-19. We performed research in the
PubMed and the Medrxiv. The trials were included if the patients were
over 12 years old, diagnosed through the rt-PCR test and who assessed as
primary outcomes or decreased mortality, or time to clinical
improvement, or hospitalization time. Random-effects meta-analysis was
used to pool individual studies. Heterogeneity was assessed using I\selectlanguage{ngerman}².
The review has been registered on PROSPERO, number 179879. Key Results:
Nine trials were included for analysis. Remdesivir, mainly early after
the onset of symptoms, led to a reduction in mortality (OR, 0·85; 95\%
CI, 0·05 to 0·98; P=0·045). Although this meta-analysis did not observe
a reduction using dexamethasone, the Recovery Trial indicates that it
can be an option for a patient that needs oxygen support. Our study did
not demonstrate the efficacy of any treatment to minimize the effects of
Covid-19 related to large hospital stay or time to clinical improvement.
Conclusion and Implications: Remdesivir is the only drug that can change
the course of Covid-19, reducing mortality rates. Despite this result,
other studies must evaluate the effectiveness of this and other drugs in
the management of Covid-19 mainly studies with robust methods.%
\end{abstract}\selectlanguage{ngerman}%



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