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\begin{document}

\title{Impact of SARS-Cov-2 on ectopic pregnancies management in the United
Kingdom: a multicentre paired observational study}



\author[1]{Sophie Platts}%
\author[1]{Jeewantha Ranawakagedon}%
\author[1]{Reeba Oliver}%
\author[2]{Sayantana Das}%
\author[3]{Phalguni Kotabagi}%
\author[4]{Christina Neophytou}%
\author[5]{Neha Shah}%
\author[2]{Matthew Toal}%
\author[2]{Amelia Davison}%
\author[6]{Mary  Gbegbaje}%
\author[5]{Kalpanas Rao}%
\author[3]{Schahrazed Rouabhi}%
\author[2]{Sandra Watson}%
\author[6]{Funlayo Odejinmi}%
\affil[1]{Whipps Cross University Hospital NHS Trust}%
\affil[2]{Homerton University Hospital}%
\affil[3]{North Middlesex University Hospital}%
\affil[4]{The Royal London Hospital}%
\affil[5]{Newham University Hospital NHS Trust}%
\affil[6]{Barts Health NHS Trust}%


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  \date{May 27, 2024}


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\begin{abstract}
Objective: to describe the impact of COVID-19 on the management of
patients with ectopic pregnancy. Design: a multicentre study comparing
outcomes from a prospective cohort during the pandemic {[}Covid-ectopic
pregnancy registry (CEPR){]} compared to an historical pre-pandemic
cohort {[}non-Covid ectopic pregnancy registry (NCEPR){]}. Setting: five
London university hospitals. Population and Methods: consecutive
patients diagnosed clinically and/or radiologically with ectopic
pregnancy (March/2020-Aug/2020) were entered into the CEPR and an
exploratory matched analysis was performed comparing results to NCEPR
patients (January/2019-June/2019). Main outcome measures: patient
demographics, management (expectant, medical and surgical), length of
treatment, number of hospital visits (non-surgical management), length
of stay (surgical management) and 30-day complications. Results: 341
patients met inclusion: 162 CEPR and 179 NCEPR. A significantly higher
percentage of women underwent non-surgical management versus surgical
management in the CEPR versus NCEPR (58.6\% {[}95/162{]} vs 72.6\%
{[}130/179{]}; p= 0.0084{]}. Amongst patients managed with expectant
management the CEPR had a significantly lower mean number of hospital
visits compared to NCEPR {[}3.6 {[}SD 1.4{]} vs 13.7 {[}SD 13.4{]}, p=
0.0053{]}. Amongst patients managed with medical management, the CEPR
had a significantly lower mean number of hospital visits {[}NCEPR 6.4
{[}SD 2.3{]} vs 8.8 {[}SD 3.9{]}, p= 0.0014{]}. There was no observed
difference in complication rates between cohorts. Conclusion: women were
found to undergo significantly higher rates of non-surgical management
during COVID-19 first wave vs NCEPR cohort. Women managed non-surgically
in CPER cohort were also managed with fewer hospital attendances. This
did not lead to an increase in observed complications rates.%
\end{abstract}%



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