4 CONCLUSION
CLA are debilitating chronic diseases that can be life-threatening.
Given the progressive nature of these conditions, early and accurate
diagnosis is essential for optimal management, which typically requires
an interdisciplinary and multimodal approach. Although CLA do not have a
cure, recent clinical and scientific discoveries have enhanced our
knowledge of the genetics and pathophysiology of these conditions and
changed the treatment paradigm, now favoring medical management to
control disease progression and complications as well as improve
symptoms and QOL.