STRING analysis
Protein-protein interaction networks were produced using STRING ver.
11.0 (Szklarczyk et al., 2019)
(https://string-db.org/) for
important groups of significant proteins, including those significantly
regulated in all treatments. Lists of accession numbers for these
significant proteins were entered in the search function “multiple
proteins”, creating network maps with line connections based on
scientific literature. Enrichment values were determined as
over-representation of list members with high or low FC in STRING
functional clusters, Uniprot keywords, and Pfam, InterPro, or SMART
protein domains with a false discovery rate (FDR) <0.05 after
correcting for multiple testing using the Benjamini-Hochberg procedure.