Abstract
Here we report the seven-year long-term survival after Aspergillus
fumigatus mediastinitis after heart transplantation, an uncommonly
described condition. A 66-year-old male developed infection withA. fumigatus covering the entire thoracic cavity with a fungal
turf after orthotopic heart transplantation. Repeated surgical removal
of infectious and necrotic tissue together with innovative topical
treatment using voriconazole and chlorhexidine combined with systemic
antifungal treatment lead to control of infection. Definitive wound
closure was achieved by standard sternal refixation and latissimus
dorsi muscle flap plasty. Survival after A. fumigatusmediastinitis after heart transplantation was achieved with sequential
debridement in combination with topical application of antifungal
agents.