Study design
The participants were divided into two non-randomized groups with 223
who had received one rectal enema on the morning of their biopsy in
Group 1 and 196 who had received an additional enema half an hour before
the procedure in Group 2. Medical records, including demographic,
clinical, and biochemical data, were collected from the hospital
database and each patient’s chart. Body temperature of more than 38°C,
dysuria, and urinary pyuria were accepted as indicating a urinary tract
infection (UTI). A sequential organ failure assessment score of more
than 2 and a positive urine culture were considered evidence of sepsis
(12). The neutrophile-lymphocyte ratio (NLR) was calculated as the
absolute number of neutrophiles divided by the lymphocyte count, and the
platelet-lymphocyte ratio (PLR) was determined by dividing the number of
platelets by the number of lymphocytes. The systemic immune-inflammatory
index (SII) was calculated as the platelet count multiplied by
neutrophiles and divided by lymphocytes.
The primary endpoint of the study was the reduction or prevention of
infective complications following prostate biopsy with a secondary goal
being the prevention of clinically essential complications that require
hospitalization. The local ethics committee approved the study.